Heliyon (Mar 2024)

Exploring cellular immunotherapy platforms in multiple myeloma

  • Manh-Cuong Vo,
  • Sung-Hoon Jung,
  • Van-Tan Nguyen,
  • Van-Dinh-Huan Tran,
  • Nodirjon Ruzimurodov,
  • Sang Ki Kim,
  • Xuan-Hung Nguyen,
  • Mihee Kim,
  • Ga-Young Song,
  • Seo-Yeon Ahn,
  • Jae-Sook Ahn,
  • Deok-Hwan Yang,
  • Hyeoung-Joon Kim,
  • Je-Jung Lee

Journal volume & issue
Vol. 10, no. 6
p. e27892

Abstract

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Despite major advances in therapeutic platforms, most patients with multiple myeloma (MM) eventually relapse and succumb to the disease. Among the novel therapeutic options developed over the past decade, genetically engineered T cells have a great deal of potential. Cellular immunotherapies, including chimeric antigen receptor (CAR) T cells, are rapidly becoming an effective therapeutic modality for MM. Marrow-infiltrating lymphocytes (MILs) derived from the bone marrow of patients with MM are a novel source of T cells for adoptive T-cell therapy, which robustly and specifically target myeloma cells. In this review, we examine the recent innovations in cellular immunotherapies, including the use of dendritic cells, and cellular tools based on MILs, natural killer (NK) cells, and CAR T cells, which hold promise for improving the efficacy and/or reducing the toxicity of treatment in patients with MM.

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