Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Yunsha Zhang; Lu Lian; Lu Lian; Lu Lian; Rong Fu; Rong Fu; Rong Fu; Jueling Liu; Jueling Liu; Jueling Liu; Xiaoqian Shan; Xiaoqian Shan; Xiaoqian Shan; Yang Jin; Shixin Xu; Shixin Xu; Shixin Xu

doi:10.3389/fncel.2022.889442

Frontiers in Cellular Neuroscience (Apr 2022)

Microglia: The Hub of Intercellular Communication in Ischemic Stroke

Yunsha Zhang,
Lu Lian,
Lu Lian,
Lu Lian,
Rong Fu,
Rong Fu,
Rong Fu,
Jueling Liu,
Jueling Liu,
Jueling Liu,
Xiaoqian Shan,
Xiaoqian Shan,
Xiaoqian Shan,
Yang Jin,
Shixin Xu,
Shixin Xu,
Shixin Xu

Affiliations

Yunsha Zhang: School of Integrative Medicine, Tianjin University of Traditional Chinese MedicineTianjin, China
Lu Lian: Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin, China
Lu Lian: Tianjin University of Traditional Chinese Medicine, Tianjin, China
Lu Lian: National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Rong Fu: Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin, China
Rong Fu: Tianjin University of Traditional Chinese Medicine, Tianjin, China
Rong Fu: National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Jueling Liu: Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin, China
Jueling Liu: Tianjin University of Traditional Chinese Medicine, Tianjin, China
Jueling Liu: National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Xiaoqian Shan: Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin, China
Xiaoqian Shan: Tianjin University of Traditional Chinese Medicine, Tianjin, China
Xiaoqian Shan: National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Yang Jin: School of Integrative Medicine, Tianjin University of Traditional Chinese MedicineTianjin, China
Shixin Xu: Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin, China
Shixin Xu: National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Shixin Xu: Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China

DOI: https://doi.org/10.3389/fncel.2022.889442
Journal volume & issue: Vol. 16

Abstract

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Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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Abstract

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