Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

Krzysztof Kucharz; Kasper Kristensen; Kasper Bendix Johnsen; Mette Aagaard Lund; Micael Lønstrup; Torben Moos; Thomas Lars Andresen; Martin Johannes Lauritzen

doi:10.1038/s41467-021-24323-1

Nature Communications (Jul 2021)

Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

Krzysztof Kucharz,
Kasper Kristensen,
Kasper Bendix Johnsen,
Mette Aagaard Lund,
Micael Lønstrup,
Torben Moos,
Thomas Lars Andresen,
Martin Johannes Lauritzen

Affiliations

Krzysztof Kucharz: Department of Neuroscience, Faculty of Health Sciences, University of Copenhagen
Kasper Kristensen: Department of Health Technology, Technical University of Denmark
Kasper Bendix Johnsen: Department of Health Technology, Technical University of Denmark
Mette Aagaard Lund: Department of Health Technology, Technical University of Denmark
Micael Lønstrup: Department of Neuroscience, Faculty of Health Sciences, University of Copenhagen
Torben Moos: Department of Health Science and Technology, Aalborg University
Thomas Lars Andresen: Department of Health Technology, Technical University of Denmark
Martin Johannes Lauritzen: Department of Neuroscience, Faculty of Health Sciences, University of Copenhagen

DOI: https://doi.org/10.1038/s41467-021-24323-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the receptor-mediated transcytosis of nanoparticles at all steps of delivery from the blood to the brain in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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