Nature Communications (Feb 2020)

Sexual-dimorphism in human immune system aging

  • Eladio J. Márquez,
  • Cheng-han Chung,
  • Radu Marches,
  • Robert J. Rossi,
  • Djamel Nehar-Belaid,
  • Alper Eroglu,
  • David J. Mellert,
  • George A. Kuchel,
  • Jacques Banchereau,
  • Duygu Ucar

DOI
https://doi.org/10.1038/s41467-020-14396-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Whether the immune system aging differs between men and women is barely known. Here the authors characterize gene expression, chromatin state and immune subset composition in the blood of healthy humans 22 to 93 years of age, uncovering shared as well as sex-unique alterations, and create a web resource to interactively explore the data.