Spreading depression as an innate antiseizure mechanism

Isra Tamim; David Y. Chung; Andreia Lopes de Morais; Inge C. M. Loonen; Tao Qin; Amrit Misra; Frieder Schlunk; Matthias Endres; Steven J. Schiff; Cenk Ayata

doi:10.1038/s41467-021-22464-x

Nature Communications (Apr 2021)

Spreading depression as an innate antiseizure mechanism

Isra Tamim,
David Y. Chung,
Andreia Lopes de Morais,
Inge C. M. Loonen,
Tao Qin,
Amrit Misra,
Frieder Schlunk,
Matthias Endres,
Steven J. Schiff,
Cenk Ayata

Affiliations

Isra Tamim: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
David Y. Chung: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
Andreia Lopes de Morais: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
Inge C. M. Loonen: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
Tao Qin: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School
Amrit Misra: Department of Neurology, Massachusetts General Hospital, Harvard Medical School
Frieder Schlunk: Charité–Universitätsmedizin Berlin, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB)
Matthias Endres: Charité–Universitätsmedizin Berlin, Klinik und Hochschulambulanz für Neurologie und Centrum für Schlaganfallforschung Berlin (CSB)
Steven J. Schiff: Center for Neural Engineering, Departments of Engineering Science and Mechanics and Physics, The Pennsylvania State University
Cenk Ayata: Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-22464-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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