Nature Communications (Jan 2017)

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

  • Stefan A. Berghoff,
  • Nina Gerndt,
  • Jan Winchenbach,
  • Sina K. Stumpf,
  • Leon Hosang,
  • Francesca Odoardi,
  • Torben Ruhwedel,
  • Carolin Böhler,
  • Benoit Barrette,
  • Ruth Stassart,
  • David Liebetanz,
  • Payam Dibaj,
  • Wiebke Möbius,
  • Julia M. Edgar,
  • Gesine Saher

DOI
https://doi.org/10.1038/ncomms14241
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Cholesterol is important for axonal myelination during development. Here the authors show that cholesterol levels are reduced in a cuprizone mouse model of multiple sclerosis and that dietary cholesterol supplementation enhances remyelination and recovery.