TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Samrat T. Kundu; Caitlin L. Grzeskowiak; Jared J. Fradette; Laura A. Gibson; Leticia B. Rodriguez; Chad J. Creighton; Kenneth L. Scott; Don L. Gibbons

doi:10.1038/s41467-018-05013-x

Nature Communications (Jul 2018)

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Samrat T. Kundu,
Caitlin L. Grzeskowiak,
Jared J. Fradette,
Laura A. Gibson,
Leticia B. Rodriguez,
Chad J. Creighton,
Kenneth L. Scott,
Don L. Gibbons

Affiliations

Samrat T. Kundu: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Caitlin L. Grzeskowiak: Department of Molecular and Human Genetics, Baylor College of Medicine
Jared J. Fradette: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Laura A. Gibson: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Leticia B. Rodriguez: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
Chad J. Creighton: Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine
Kenneth L. Scott: Department of Molecular and Human Genetics, Baylor College of Medicine
Don L. Gibbons: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-05013-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cells, increasing metastatic spreading.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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