Nature Communications (Sep 2019)
Characterizing rare and low-frequency height-associated variants in the Japanese population
- Masato Akiyama,
- Kazuyoshi Ishigaki,
- Saori Sakaue,
- Yukihide Momozawa,
- Momoko Horikoshi,
- Makoto Hirata,
- Koichi Matsuda,
- Shiro Ikegawa,
- Atsushi Takahashi,
- Masahiro Kanai,
- Sadao Suzuki,
- Daisuke Matsui,
- Mariko Naito,
- Taiki Yamaji,
- Motoki Iwasaki,
- Norie Sawada,
- Kozo Tanno,
- Makoto Sasaki,
- Atsushi Hozawa,
- Naoko Minegishi,
- Kenji Wakai,
- Shoichiro Tsugane,
- Atsushi Shimizu,
- Masayuki Yamamoto,
- Yukinori Okada,
- Yoshinori Murakami,
- Michiaki Kubo,
- Yoichiro Kamatani
Affiliations
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Kazuyoshi Ishigaki
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Saori Sakaue
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yukihide Momozawa
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Momoko Horikoshi
- Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
- Makoto Hirata
- Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo
- Koichi Matsuda
- Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo
- Shiro Ikegawa
- Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
- Atsushi Takahashi
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Masahiro Kanai
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Sadao Suzuki
- Nagoya City University Graduate School of Medical Sciences
- Daisuke Matsui
- Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
- Mariko Naito
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Taiki Yamaji
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Motoki Iwasaki
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Norie Sawada
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Kozo Tanno
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Makoto Sasaki
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Atsushi Hozawa
- Tohoku Medical Megabank Organization, Tohoku University
- Naoko Minegishi
- Tohoku Medical Megabank Organization, Tohoku University
- Kenji Wakai
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Shoichiro Tsugane
- Center for Public Health Sciences, National Cancer Center
- Atsushi Shimizu
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Masayuki Yamamoto
- Tohoku Medical Megabank Organization, Tohoku University
- Yukinori Okada
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yoshinori Murakami
- Division of Molecular Pathology, The Institute of Medical Science, The University of Tokyo
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-019-12276-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Thousands of genetic loci are known to associate with human height, but these are mainly based on studies in European ancestry populations. Here, Akiyama et al. construct a genotype reference panel for the Japanese population followed by GWAS and report 573 height associated variants in 191,787 Japanese.
