l-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions

Abstract

Catalysis field wherein a tiny organic molecule like l-proline is an efficient and selectively catalyzed organic reaction. Catalyst-supported organic synthesis is confirmed to be involved in the fast synthesis of novel compounds with selectivity and enhanced biological activities. l-proline catalyzed reactions are valuable tools for the making of different heterocycles, acyclic, and carbocyclic scaffolds that signify the main framework of most of the bio-active compounds. A few decades ago, novel tools for the manufacturing of bio-active molecules had a huge impact on organic chemistry. Subsequently, the synthesis of biologically important heterocycles through a synthetically proficient and environmentally benign route is the important purpose of modern synthetic chemistry. In this review, we discuss only l-proline catalyzed organic reactions (including condensation, addition, asymmetric, multi-components, and other modular reactions) for the sustainable synthesis of biologically promising heterocycles in a single trencher that may provide as a piece of reliable literature for further research in this field.

Keywords

• Organocatalysis
• l-proline
• Bio-activity of heterocycles
• one pot multi-component reactions and synthesis of heterocycles