Nature Communications (Jan 2018)

Pixelated spatial gene expression analysis from tissue

  • A. Ganguli,
  • A. Ornob,
  • N. Spegazzini,
  • Y. Liu,
  • G. Damhorst,
  • T. Ghonge,
  • B. Thornton,
  • C. J. Konopka,
  • W. Dobrucki,
  • S. E. Clare,
  • R. Bhargava,
  • A. M. Smith,
  • F. Kosari,
  • R. Bashir

DOI
https://doi.org/10.1038/s41467-017-02623-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Spatial localization of genetic information is important for tissue heterogeneity but difficult to capture with current analytical techniques. Here the authors present “Pixelated RT-LAMP”, an approach that uses parallel on-chip reactions to provide the distribution of target sequences directly from tissue.