Dietary stearic acid regulates mitochondria in vivo in humans

Deniz Senyilmaz-Tiebe; Daniel H. Pfaff; Sam Virtue; Kathrin V. Schwarz; Thomas Fleming; Sandro Altamura; Martina U. Muckenthaler; Jürgen G. Okun; Antonio Vidal-Puig; Peter Nawroth; Aurelio A. Teleman

doi:10.1038/s41467-018-05614-6

Nature Communications (Aug 2018)

Dietary stearic acid regulates mitochondria in vivo in humans

Deniz Senyilmaz-Tiebe,
Daniel H. Pfaff,
Sam Virtue,
Kathrin V. Schwarz,
Thomas Fleming,
Sandro Altamura,
Martina U. Muckenthaler,
Jürgen G. Okun,
Antonio Vidal-Puig,
Peter Nawroth,
Aurelio A. Teleman

Affiliations

Deniz Senyilmaz-Tiebe: German Cancer Research Center (DKFZ)
Daniel H. Pfaff: German Cancer Research Center (DKFZ)
Sam Virtue: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Kathrin V. Schwarz: Center for Child and Adolescent Medicine, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg
Thomas Fleming: Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital
Sandro Altamura: Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg
Martina U. Muckenthaler: Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg
Jürgen G. Okun: Center for Child and Adolescent Medicine, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg
Antonio Vidal-Puig: University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science
Peter Nawroth: Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital
Aurelio A. Teleman: German Cancer Research Center (DKFZ)

DOI: https://doi.org/10.1038/s41467-018-05614-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Dietary fatty acids have different effects on human health. Here, the authors show that ingestion of the fatty acid C18:0, but not of C16:0, rapidly leads to fusion of mitochondria and fatty acid oxidation in humans, possibly explaining the health benefits of C18:0.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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