Nature Communications (Nov 2018)

Calcium stabilizes the strongest protein fold

  • Lukas F. Milles,
  • Eduard M. Unterauer,
  • Thomas Nicolaus,
  • Hermann E. Gaub

DOI
https://doi.org/10.1038/s41467-018-07145-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.