Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis

Abstract

Wound healing is a dynamic event where barrier disruption is transient and miR-198/FSTL1 molecular switch orchestrate wound re-epithelialization. However, epithelial carcinomas maintain a prolonged wound-healing phase to promote malignant transformation. Delineating the molecular mechanism we demonstrate, how epidermal growth factor (EGF) hijacks the wound-healing switch to promote metastasis of carcinoma.

Keywords

• microrna
• egf
• cancer
• molecular switch
• biology of malignant cells and metastasis