An outbreak of rhinovirus infection in a primary school in Shenyang City, China, in 2022

Yage Wang; Jiayuan Liang; Zhibo Xie; Bing Wang; Jinhua Song; Baicheng Xia; Huiling Wang; Yao Zhang; Ye Chen; Ling Chen; Shi Cong; Yu Liu; Aili Cui; Yan Zhang

Biosafety and Health (Oct 2024)

An outbreak of rhinovirus infection in a primary school in Shenyang City, China, in 2022

Yage Wang,
Jiayuan Liang,
Zhibo Xie,
Bing Wang,
Jinhua Song,
Baicheng Xia,
Huiling Wang,
Yao Zhang,
Ye Chen,
Ling Chen,
Shi Cong,
Yu Liu,
Aili Cui,
Yan Zhang

Affiliations

Yage Wang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Jiayuan Liang: Liaoning Provincial Center for Disease Prevention and Control, Shenyang 110000, China
Zhibo Xie: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Bing Wang: Shenyang Prefecture Center for Disease Control and Prevention, Shenyang 110031, China
Jinhua Song: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Baicheng Xia: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Huiling Wang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Yao Zhang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Ye Chen: Shenyang Prefecture Center for Disease Control and Prevention, Shenyang 110031, China
Ling Chen: Shenyang Medical College, Shenyang 110034, China
Shi Cong: Shenyang Medical College, Shenyang 110034, China
Yu Liu: Yuhong District Center for Disease Control and Prevention, Shenyang 110146, China
Aili Cui: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Yan Zhang: National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Corresponding author: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Journal volume & issue: Vol. 6, no. 5
pp. 298 – 303

Abstract

Read online

Rhinovirus (RV) is a common pathogen that causes respiratory tract infection and can cause outbreaks in hospitals and welfare institutions. A cluster of respiratory diseases occurred in a primary school in Shenyang City, Liaoning Province, China, in 2022. In this outbreak, a total of 31 students had symptoms similar to those of upper respiratory tract infection, mainly cough and sore throat. Among them, 27 throat swabs were collected and identified for respiratory pathogens by TaqMan low-density array (TLDA), quantitative real-time polymerase chain reaction (PCR), reverse transcription-nested PCR and whole-genome sequencing. Out of the 27 specimens, 24 tested positive for RV, and 21 RV viral protein 1 sequences were obtained, of which 15 (71.43%) were identified as RV-A49, while 2 RV-A20 and 4 sequences from 2 specimens were RV-A30 coinfected with RV-C15. In addition, one whole-genome sequence (WGS) of RV-A49 was obtained, and three unique amino acid mutations were found compared to 23 WGS of RV-A49 from GenBank. In conclusion, this outbreak of upper respiratory tract infection is caused by RV, mainly RV-A49.

Published in Biosafety and Health

ISSN: 2590-0536 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/biosafety-and-health/

About the journal

Abstract

Keywords