Evaluation of repolarization dispersion in patients with idiopathic pulmonary fibrosis

Abstract

Idiopathic pulmonary fibrosis (IPF) is a serious lung disease of unknown etiology and characterized by interstitial fibrosis. The patients usually present with potentially fatal cardiac arrhythmias. This study aimed to investigate indicators of arrhythmia based on electrocardiography (ECG) in patients with IPF. ECG indicators of ventricular depolarization (VD) and repolarization (VR) (QT, QTc, QTd, QTdc, Tp-e, JT and JTc intervals, Tp-e / QT ratio, Tp-e / QTc ratio, Tp-e / JT ratio, and Tp-e / JTc ratio) were analyzed retrospectively in patients with IPF (n:52) and compared with the healthy control group (n:52). The mean QRS interval was lower in patients with IPF compared to the control group, indicators of VD and VR were higher in patients with IPF compared to the control group (p < 0.05). A positive correlation was found between indicators of VD and VR and inflammation markers (CRP and cTn-I) (p < 0.05). We found that indicators of VD and VR were higher in patients with IPF and that is positively correlated with inflammatory markers. Inflammation in cases of IPF may be associated with the development of malignant or chronic cardiac arrhythmias. [Med-Science 2022; 11(2.000): 677-81]

Keywords

• arrhythmias
• electrocardiography
• idiopathic pulmonary fibrosis
• repolarization