In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Henrik Gutte; Adam E. Hansen; Majbrit M.E. Larsen; Sofie Rahbek; Helle H. Johannesen; Jan Ardenkjaer-Larsen; Annemarie T. Kristensen; Liselotte Højgaard; Andreas Kjaer

doi:10.3390/diagnostics5030287

Diagnostics (Jun 2015)

In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

Henrik Gutte,
Adam E. Hansen,
Majbrit M.E. Larsen,
Sofie Rahbek,
Helle H. Johannesen,
Jan Ardenkjaer-Larsen,
Annemarie T. Kristensen,
Liselotte Højgaard,
Andreas Kjaer

Affiliations

Henrik Gutte: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Adam E. Hansen: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Majbrit M.E. Larsen: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
Sofie Rahbek: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Helle H. Johannesen: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Jan Ardenkjaer-Larsen: Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark
Annemarie T. Kristensen: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
Liselotte Højgaard: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
Andreas Kjaer: Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark

DOI: https://doi.org/10.3390/diagnostics5030287
Journal volume & issue: Vol. 5, no. 3
pp. 287 – 289

Abstract

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In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors.

Published in Diagnostics

ISSN: 2075-4418 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.mdpi.com/journal/diagnostics

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