Nature Communications (Aug 2020)
Genomic characterization of malignant progression in neoplastic pancreatic cysts
- Michaël Noë,
- Noushin Niknafs,
- Catherine G. Fischer,
- Wenzel M. Hackeng,
- Violeta Beleva Guthrie,
- Waki Hosoda,
- Marija Debeljak,
- Eniko Papp,
- Vilmos Adleff,
- James R. White,
- Claudio Luchini,
- Antonio Pea,
- Aldo Scarpa,
- Giovanni Butturini,
- Giuseppe Zamboni,
- Paola Castelli,
- Seung-Mo Hong,
- Shinichi Yachida,
- Nobuyoshi Hiraoka,
- Anthony J. Gill,
- Jaswinder S. Samra,
- G. Johan A. Offerhaus,
- Anne Hoorens,
- Joanne Verheij,
- Casper Jansen,
- N. Volkan Adsay,
- Wei Jiang,
- Jordan Winter,
- Jorge Albores-Saavedra,
- Benoit Terris,
- Elizabeth D. Thompson,
- Nicholas J. Roberts,
- Ralph H. Hruban,
- Rachel Karchin,
- Robert B. Scharpf,
- Lodewijk A. A. Brosens,
- Victor E. Velculescu,
- Laura D. Wood
Affiliations
- Michaël Noë
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Noushin Niknafs
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Catherine G. Fischer
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Wenzel M. Hackeng
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Violeta Beleva Guthrie
- Institute for Computational Medicine, Johns Hopkins University
- Waki Hosoda
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Marija Debeljak
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Eniko Papp
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Vilmos Adleff
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- James R. White
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Claudio Luchini
- Department of Diagnostics and Public Health, Section of Pathology, University of Verona
- Antonio Pea
- Department of Surgery – The Pancreas Institute, University and Hospital Trust of Verona
- Aldo Scarpa
- Department of Diagnostics and Public Health, Section of Pathology, University of Verona
- Giovanni Butturini
- Department of Surgery, Pederzoli Hospital
- Giuseppe Zamboni
- Department of Diagnostics and Public Health, Section of Pathology, University of Verona
- Paola Castelli
- Pathology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar
- Seung-Mo Hong
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Shinichi Yachida
- Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University
- Nobuyoshi Hiraoka
- Department of Pathology and Clinical Laboratories, National Cancer Center Hospital
- Anthony J. Gill
- University of Sydney
- Jaswinder S. Samra
- University of Sydney
- G. Johan A. Offerhaus
- Department of Pathology, The University Medical Center Utrecht
- Anne Hoorens
- Department of Pathology, Ghent University Hospital
- Joanne Verheij
- Department of Pathology, Academic Medical Center
- Casper Jansen
- LABPON, Laboratory for Pathology Eastern Netherlands
- N. Volkan Adsay
- Koc University School of Medicine
- Wei Jiang
- Department of Pathology, Thomas Jefferson University
- Jordan Winter
- University Hospitals Cleveland Medical Center and Seidman Cancer Center
- Jorge Albores-Saavedra
- Department of Pathology, Medica Sur Clinic and Foundation
- Benoit Terris
- Service de Pathologie, AP-HP, Hôpital Cochin, Université Paris Descartes
- Elizabeth D. Thompson
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Nicholas J. Roberts
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Ralph H. Hruban
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Rachel Karchin
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Robert B. Scharpf
- Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Lodewijk A. A. Brosens
- Department of Pathology, The University Medical Center Utrecht
- Victor E. Velculescu
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- Laura D. Wood
- Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17917-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.
