Communications Biology (Mar 2023)

Rare sugar l-sorbose exerts antitumor activity by impairing glucose metabolism

  • Hui-Lin Xu,
  • Xiaoman Zhou,
  • Shuai Chen,
  • Si Xu,
  • Zijie Li,
  • Hideki Nakanishi,
  • Xiao-Dong Gao

DOI
https://doi.org/10.1038/s42003-023-04638-z
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 17

Abstract

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The rare sugar L-sorbose is shown to decrease cell viability and increase apoptotic cells in culture and to enhance the effect of tumor chemotherapy in combination with sorafenib in mouse xenograft models.