Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell

Ting Gong; Xuedi Zhang; Zhiyong Peng; Yinfeng Ye; Ruimeng Liu; Yinggui Yang; Zhugui Chen; Zhihao Zhang; Hongfei Hu; Shuang Yin; Yi Xu; Jing Tang; Youtan Liu

doi:10.1038/s42003-022-03481-y

Communications Biology (Jun 2022)

Macrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell

Ting Gong,
Xuedi Zhang,
Zhiyong Peng,
Yinfeng Ye,
Ruimeng Liu,
Yinggui Yang,
Zhugui Chen,
Zhihao Zhang,
Hongfei Hu,
Shuang Yin,
Yi Xu,
Jing Tang,
Youtan Liu

Affiliations

Ting Gong: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Xuedi Zhang: Department of Anaesthetics, Affiliated Hospital of Guangdong Medical University
Zhiyong Peng: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Yinfeng Ye: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Ruimeng Liu: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Yinggui Yang: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Zhugui Chen: Department of Anesthesiology, Central People’s Hospital of Zhanjiang
Zhihao Zhang: Department of Anesthesiology, The First People’s Hospital of Foshan
Hongfei Hu: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Shuang Yin: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Yi Xu: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University
Jing Tang: Department of Anaesthetics, Affiliated Hospital of Guangdong Medical University
Youtan Liu: Department of Anesthesiology, Shenzhen Hospital, Southern Medical University

DOI: https://doi.org/10.1038/s42003-022-03481-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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Necroptosis of lung epithelial cells is regulated by aminopeptidase N levels in circulating plasma exosomes in patients and mice with sepsis-induced acute lung injury.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal