B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

Vinay S. Mahajan; Hamid Mattoo; Na Sun; Vinayak Viswanadham; Grace J. Yuen; Hugues Allard-Chamard; Maimuna Ahmad; Samuel J. H. Murphy; Annaiah Cariappa; Yesim Tuncay; Shiv Pillai

doi:10.1038/s41467-021-22458-9

Nature Communications (Apr 2021)

B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

Vinay S. Mahajan,
Hamid Mattoo,
Na Sun,
Vinayak Viswanadham,
Grace J. Yuen,
Hugues Allard-Chamard,
Maimuna Ahmad,
Samuel J. H. Murphy,
Annaiah Cariappa,
Yesim Tuncay,
Shiv Pillai

Affiliations

Vinay S. Mahajan: Ragon Institute of MGH, MIT, and Harvard
Hamid Mattoo: Ragon Institute of MGH, MIT, and Harvard
Na Sun: Ragon Institute of MGH, MIT, and Harvard
Vinayak Viswanadham: Ragon Institute of MGH, MIT, and Harvard
Grace J. Yuen: Ragon Institute of MGH, MIT, and Harvard
Hugues Allard-Chamard: Ragon Institute of MGH, MIT, and Harvard
Maimuna Ahmad: Ragon Institute of MGH, MIT, and Harvard
Samuel J. H. Murphy: Ragon Institute of MGH, MIT, and Harvard
Annaiah Cariappa: Ragon Institute of MGH, MIT, and Harvard
Yesim Tuncay: Ragon Institute of MGH, MIT, and Harvard
Shiv Pillai: Ragon Institute of MGH, MIT, and Harvard

DOI: https://doi.org/10.1038/s41467-021-22458-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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