Anais Brasileiros de Dermatologia (Oct 2016)

Syndrome in question: antisynthetase syndrome (anti-PL-7)

  • Ana Cláudia Cavalcante Esposito,
  • Tatiana Cristina Gige,
  • Hélio Amante Miot

DOI
https://doi.org/10.1590/abd1806-4841.20164449
Journal volume & issue
Vol. 91, no. 5
pp. 683 – 685

Abstract

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Abstract: Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by other immunosuppressants. The prognosis of the disease is quite limited when compared to other inflammatory myopathies with negative antisynthetase antibodies.

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