Haematologica (Aug 2007)

FcγRIIIA and FcγRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin’s lymphoma patients treated with sequential CHOP and rituximab

  • Emanuela Carlotti,
  • Giuseppe A. Palumbo,
  • Elena Oldani,
  • Daniele Tibullo,
  • Silvia Salmoiraghi,
  • Andrea Rossi,
  • Josee Golay,
  • Alessandro Pulsoni,
  • Robin Foà,
  • Alessandro Rambaldi

DOI
https://doi.org/10.3324/haematol.11288
Journal volume & issue
Vol. 92, no. 8

Abstract

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We analyzed FcγRIIIA-158V/F and FcγRIIA-131H/R polymorphisms in a cohort of 94 newly diagnosed follicular lymphoma (FL) patients sequentially treated with CHOP and Rituximab. With a median follow-up of 5.8 years, the overall survival at 8 years is 83%. Univariate and multivariate analysis showed no correlation between FcγRIIIA-158VV/VF and FcγRIIA-131HH/HR polymorphisms and the overall response rate, the molecular response and the event-free survival obtained after CHOP and Rituximab. By contrast, the achievement of a durable molecular clearance of BCL2/IgH+ cells detectable in the bone marrow is confirmed to be a reliable predictive factor of a better long-term clinical outcome.