Nature Communications (Dec 2021)
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R
- Tal M. Dankovich,
- Rahul Kaushik,
- Linda H. M. Olsthoorn,
- Gabriel Cassinelli Petersen,
- Philipp Emanuel Giro,
- Verena Kluever,
- Paola Agüi-Gonzalez,
- Katharina Grewe,
- Guobin Bao,
- Sabine Beuermann,
- Hannah Abdul Hadi,
- Jose Doeren,
- Simon Klöppner,
- Benjamin H. Cooper,
- Alexander Dityatev,
- Silvio O. Rizzoli
Affiliations
- Tal M. Dankovich
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Rahul Kaushik
- Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
- Linda H. M. Olsthoorn
- International Max Planck Research School for Neuroscience
- Gabriel Cassinelli Petersen
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Philipp Emanuel Giro
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Verena Kluever
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Paola Agüi-Gonzalez
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Katharina Grewe
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Guobin Bao
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Sabine Beuermann
- Max Planck Institute for Experimental Medicine
- Hannah Abdul Hadi
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Jose Doeren
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Simon Klöppner
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- Benjamin H. Cooper
- Max Planck Institute for Experimental Medicine
- Alexander Dityatev
- Molecular Neuroplasticity, German Center for Neurodegenerative Diseases (DZNE)
- Silvio O. Rizzoli
- University Medical Center Göttingen, Institute for Neuro- and Sensory Physiology, Excellence Cluster Multiscale Bioimaging
- DOI
- https://doi.org/10.1038/s41467-021-27462-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 23
Abstract
Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis. Here, the authors show an alternative molecular recycling mechanism that occurs for the key ECM protein Tenascin-R.
