Nature Communications (Jan 2020)
The in vivo genetic program of murine primordial lung epithelial progenitors
- Laertis Ikonomou,
- Michael J. Herriges,
- Sara L. Lewandowski,
- Robert Marsland,
- Carlos Villacorta-Martin,
- Ignacio S. Caballero,
- David B. Frank,
- Reeti M. Sanghrajka,
- Keri Dame,
- Maciej M. Kańduła,
- Julia Hicks-Berthet,
- Matthew L. Lawton,
- Constantina Christodoulou,
- Attila J. Fabian,
- Eric Kolaczyk,
- Xaralabos Varelas,
- Edward E. Morrisey,
- John M. Shannon,
- Pankaj Mehta,
- Darrell N. Kotton
Affiliations
- Laertis Ikonomou
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Michael J. Herriges
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Sara L. Lewandowski
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Robert Marsland
- Department of Physics, Boston University
- Carlos Villacorta-Martin
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Ignacio S. Caballero
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- David B. Frank
- Division of Pediatric Cardiology, Department of Pediatrics, The Children’s Hospital of Philadelphia
- Reeti M. Sanghrajka
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Keri Dame
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Maciej M. Kańduła
- Department of Mathematics & Statistics, Boston University
- Julia Hicks-Berthet
- Department of Biochemistry, Boston University School of Medicine
- Matthew L. Lawton
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- Constantina Christodoulou
- The Pulmonary Center and Department of Medicine, Boston University School of Medicine
- Attila J. Fabian
- Biogen Inc.
- Eric Kolaczyk
- Department of Mathematics & Statistics, Boston University
- Xaralabos Varelas
- Department of Biochemistry, Boston University School of Medicine
- Edward E. Morrisey
- Penn Center for Pulmonary Biology, University of Pennsylvania
- John M. Shannon
- Division of Pulmonary Biology, Cincinnati Children’s Hospital
- Pankaj Mehta
- Department of Physics, Boston University
- Darrell N. Kotton
- Center for Regenerative Medicine, Boston University and Boston Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-14348-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
The identity of the earliest murine in vivo lung epithelial progenitors (marked by NKX2-1 expression) is unclear. Here, the authors use single-cell RNA sequencing to define the genetic program of these lung primordial progenitors, which will improve in vitro lung specification of pluripotent stem cells.
