Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

Ibrahim Aldoss; Tracey Stiller; Ni-Chun Tsai; Joo Y. Song; Thai Cao; N. Achini Bandara; Amandeep Salhotra; Samer Khaled; Ahmed Aribi; Monzr M. Al Malki; Matthew Mei; Haris Ali; Ricardo Spielberger; Margaret O’Donnell; David Snyder; Thomas Slavin; Ryotaro Nakamura; Anthony S. Stein; Stephen J. Forman; Guido Marcucci; Vinod Pullarkat

doi:10.3324/haematol.2018.193599

Haematologica (Oct 2018)

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

Ibrahim Aldoss,
Tracey Stiller,
Ni-Chun Tsai,
Joo Y. Song,
Thai Cao,
N. Achini Bandara,
Amandeep Salhotra,
Samer Khaled,
Ahmed Aribi,
Monzr M. Al Malki,
Matthew Mei,
Haris Ali,
Ricardo Spielberger,
Margaret O’Donnell,
David Snyder,
Thomas Slavin,
Ryotaro Nakamura,
Anthony S. Stein,
Stephen J. Forman,
Guido Marcucci,
Vinod Pullarkat

Affiliations

Ibrahim Aldoss: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Tracey Stiller: Department of Information Sciences, Division of Biostatistics, City of Hope, Duarte, CA, USA
Ni-Chun Tsai: Department of Information Sciences, Division of Biostatistics, City of Hope, Duarte, CA, USA
Joo Y. Song: Department of Pathology, City of Hope, Duarte, CA, USA
Thai Cao: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA;Kaiser Permanente, Department of BMT, Southern California Medical Group, Los Angeles
N. Achini Bandara: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Amandeep Salhotra: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Samer Khaled: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Ahmed Aribi: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Monzr M. Al Malki: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Matthew Mei: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Haris Ali: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Ricardo Spielberger: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA;Kaiser Permanente, Department of BMT, Southern California Medical Group, Los Angeles
Margaret O’Donnell: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
David Snyder: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Thomas Slavin: Department of Medical Oncology, Division of Clinical Genetics, City of Hope, Duarte, CA, USA
Ryotaro Nakamura: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Anthony S. Stein: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Stephen J. Forman: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Guido Marcucci: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA
Vinod Pullarkat: Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA, USA

DOI: https://doi.org/10.3324/haematol.2018.193599
Journal volume & issue: Vol. 103, no. 10

Abstract

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Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity. We reviewed all consecutive cases of adult acute lymphoblastic leukemia treated at our institution between 2000 and 2017 and identified therapy-related cases - defined as acute lymphoblastic leukemia preceded by prior exposure to cytotoxic chemotherapy and/or radiation. Of 1022 patients with acute lymphoblastic leukemia, 93 (9.1%) were classified as therapy-related. The median latency for therapy-related acute lymphoblastic leukemia onset was 6.8 years from original diagnosis, and this was shorter for patients carrying the MLL gene rearrangement compared to those with other cytogenetics. When compared to de novo acute lymphoblastic leukemia, therapy-related patients were older (P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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