Malaria Journal (May 2012)
Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with <it>Plasmodium falciparum</it> malaria after returning from Tanzania
Abstract
Abstract Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.
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