Nature Communications (Sep 2021)
Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
- Jaime Alvarez-Benayas,
- Nikolaos Trasanidis,
- Alexia Katsarou,
- Kanagaraju Ponnusamy,
- Aristeidis Chaidos,
- Philippa C. May,
- Xiaolin Xiao,
- Marco Bua,
- Maria Atta,
- Irene A. G. Roberts,
- Holger W. Auner,
- Evdoxia Hatjiharissi,
- Maria Papaioannou,
- Valentina S. Caputo,
- Ian M. Sudbery,
- Anastasios Karadimitris
Affiliations
- Jaime Alvarez-Benayas
- Department of Molecular Biology and Biotechnology, University of Sheffield
- Nikolaos Trasanidis
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Alexia Katsarou
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Kanagaraju Ponnusamy
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Aristeidis Chaidos
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Philippa C. May
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Xiaolin Xiao
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Marco Bua
- Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust
- Maria Atta
- Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust
- Irene A. G. Roberts
- MRC Molecular Haematology Unit and Paediatrics, MRC Weatherall Institute of Molecular Medicine
- Holger W. Auner
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Evdoxia Hatjiharissi
- First Department of Internal Medicine, Division of Haematology, AHEPA University Hospital, Aristotle University of Thessaloniki
- Maria Papaioannou
- First Department of Internal Medicine, Division of Haematology, AHEPA University Hospital, Aristotle University of Thessaloniki
- Valentina S. Caputo
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- Ian M. Sudbery
- Department of Molecular Biology and Biotechnology, University of Sheffield
- Anastasios Karadimitris
- Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-021-25704-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Despite extensive genetic heterogeneity, nearly half of all multiple myeloma (MM) cases are driven by cyclin D2 (CCND2) over-expression. Here the authors dissect the chromatin landscape of MM to provide insights into the transcriptional regulatory landscape driving MM and divergent transcriptomes corresponding to different MM genetic subtypes.
