Nature Communications (Dec 2019)
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
- Zhiyong Wang,
- Victoria H. Wu,
- Michael M. Allevato,
- Mara Gilardi,
- Yudou He,
- Juan Luis Callejas-Valera,
- Lynn Vitale-Cross,
- Daniel Martin,
- Panomwat Amornphimoltham,
- James Mcdermott,
- Bryan S. Yung,
- Yusuke Goto,
- Alfredo A. Molinolo,
- Andrew B. Sharabi,
- Ezra E. W. Cohen,
- Qianming Chen,
- J. Guy Lyons,
- Ludmil B. Alexandrov,
- J. Silvio Gutkind
Affiliations
- Zhiyong Wang
- Moores Cancer Center, University of California San Diego
- Victoria H. Wu
- Moores Cancer Center, University of California San Diego
- Michael M. Allevato
- Moores Cancer Center, University of California San Diego
- Mara Gilardi
- Moores Cancer Center, University of California San Diego
- Yudou He
- Department of Cellular and Molecular Medicine, University of California San Diego
- Juan Luis Callejas-Valera
- Cancer Biology and Immunotherapies Group, Sanford Research
- Lynn Vitale-Cross
- National Institute of Dental and Craniofacial Research, National Institutes of Health
- Daniel Martin
- National Institute of Dental and Craniofacial Research, National Institutes of Health
- Panomwat Amornphimoltham
- International College of Dentistry, Walailak University
- James Mcdermott
- Moores Cancer Center, University of California San Diego
- Bryan S. Yung
- Moores Cancer Center, University of California San Diego
- Yusuke Goto
- Moores Cancer Center, University of California San Diego
- Alfredo A. Molinolo
- Moores Cancer Center, University of California San Diego
- Andrew B. Sharabi
- Moores Cancer Center, University of California San Diego
- Ezra E. W. Cohen
- Moores Cancer Center, University of California San Diego
- Qianming Chen
- State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
- J. Guy Lyons
- Dermatology, Bosch Institute, University of Sydney
- Ludmil B. Alexandrov
- Moores Cancer Center, University of California San Diego
- J. Silvio Gutkind
- Moores Cancer Center, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-019-13471-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Tobacco use is one of the major risk factors for Head and neck squamous cell carcinoma (HNSCC). Here, the authors report an immune-competent syngeneic mouse model that mimics human tobacco-related HNSCC, and develops tumors in the tongue, and report a high response rate to anti-CTLA-4 therapy.
