Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor

Amin Sherafat; Friederike Pfeiffer; Alexander M. Reiss; William M. Wood; Akiko Nishiyama

doi:10.1038/s41467-021-22532-2

Nature Communications (Apr 2021)

Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor

Amin Sherafat,
Friederike Pfeiffer,
Alexander M. Reiss,
William M. Wood,
Akiko Nishiyama

Affiliations

Amin Sherafat: Department of Physiology and Neurobiology, University of Connecticut
Friederike Pfeiffer: Department of Physiology and Neurobiology, University of Connecticut
Alexander M. Reiss: Department of Physiology and Neurobiology, University of Connecticut
William M. Wood: Department of Physiology and Neurobiology, University of Connecticut
Akiko Nishiyama: Department of Physiology and Neurobiology, University of Connecticut

DOI: https://doi.org/10.1038/s41467-021-22532-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Oligodendrocyte precursor cell (OPC) proliferation and differentiation is greater in white matter than gray matter. Here, the authors show regulation of OPC proliferation in white matter involved trans-activation of PDGFRα on OPCs via Nrp1 expressed by adjacent microglia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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