Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes

Manish Debnath; Sandipan Chakraborty; Y. Pavan Kumar; Ritapa Chaudhuri; Biman Jana; Jyotirmayee Dash

doi:10.1038/s41467-019-13834-7

Nature Communications (Jan 2020)

Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes

Manish Debnath,
Sandipan Chakraborty,
Y. Pavan Kumar,
Ritapa Chaudhuri,
Biman Jana,
Jyotirmayee Dash

Affiliations

Manish Debnath: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur
Sandipan Chakraborty: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur
Y. Pavan Kumar: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur
Ritapa Chaudhuri: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur
Biman Jana: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur
Jyotirmayee Dash: School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur

DOI: https://doi.org/10.1038/s41467-019-13834-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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DNA based ionophores can mediate efficient ion transport and are crucial to understand the biological role of their natural counterparts. Here authors engineer a telomeric DNA G-quadruplex based ionophore which transports K+ in a stimuli responsive manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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