Nature Communications (Dec 2019)
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
- Huifen Cao,
- Lorena Salazar-García,
- Fan Gao,
- Thor Wahlestedt,
- Chun-Lin Wu,
- Xueer Han,
- Ye Cai,
- Dongyang Xu,
- Fang Wang,
- Lu Tang,
- Natalie Ricciardi,
- DingDing Cai,
- Huifang Wang,
- Mario P. S. Chin,
- James A. Timmons,
- Claes Wahlestedt,
- Philipp Kapranov
Affiliations
- Huifen Cao
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Lorena Salazar-García
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Fan Gao
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Thor Wahlestedt
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Chun-Lin Wu
- Department of Pathology, Second Affiliated Hospital of Fujian Medical University
- Xueer Han
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Ye Cai
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Dongyang Xu
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Fang Wang
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Lu Tang
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Natalie Ricciardi
- Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine
- DingDing Cai
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Huifang Wang
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- Mario P. S. Chin
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- James A. Timmons
- Augur Precision Medicine LTD, Scion House, Stirling University Innovation Park
- Claes Wahlestedt
- Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine
- Philipp Kapranov
- Institute of Genomics, School of Biomedical Sciences, Huaqiao University
- DOI
- https://doi.org/10.1038/s41467-019-13602-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Single strand breaks represent the most common form of DNA damage yet no methods to map them in a genome-wide fashion at single nucleotide resolution exist. Here the authors develop such a method and apply to uncover patterns of single-strand DNA “breakome” in different biological conditions.
