G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

Chandrani Mukhopadhyay; Chenyi Yang; Limei Xu; Deli Liu; Yu Wang; Dennis Huang; Lesa Dayal Deonarine; Joanna Cyrta; Elai Davicioni; Andrea Sboner; Brian. D. Robinson; Arul M. Chinnaiyan; Mark A. Rubin; Christopher E. Barbieri; Pengbo Zhou

doi:10.1038/s41467-021-27024-x

Nature Communications (Nov 2021)

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer

Chandrani Mukhopadhyay,
Chenyi Yang,
Limei Xu,
Deli Liu,
Yu Wang,
Dennis Huang,
Lesa Dayal Deonarine,
Joanna Cyrta,
Elai Davicioni,
Andrea Sboner,
Brian. D. Robinson,
Arul M. Chinnaiyan,
Mark A. Rubin,
Christopher E. Barbieri,
Pengbo Zhou

Affiliations

Chandrani Mukhopadhyay: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Chenyi Yang: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Limei Xu: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Deli Liu: Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Yu Wang: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Dennis Huang: Department of Urology, Weill Cornell Medicine
Lesa Dayal Deonarine: Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Joanna Cyrta: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Elai Davicioni: GenomeDx Bioscience
Andrea Sboner: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Brian. D. Robinson: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Arul M. Chinnaiyan: Michigan Center for Translational Pathology, University of Michigan
Mark A. Rubin: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University
Christopher E. Barbieri: Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine
Pengbo Zhou: Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University

DOI: https://doi.org/10.1038/s41467-021-27024-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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SPOP functions as a tumour suppressor in prostate cancer but how the protein is regulated is unclear. Here, the authors identify G3BP1 as a competitive inhibitor of SPOP and show that G3BP1-SPOP axis activates androgen signalling to drive tumorigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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