Thoracic Cancer (Jan 2024)

Kristen rat sarcoma virus (KRAS) G12F‐positive non‐small cell lung cancer mimicking KRAS G12C positivity: A case report

  • Issei Oi,
  • Takanori Ito,
  • Zentaro Saito,
  • Takuma Imakita,
  • Osamu Kanai,
  • Kohei Fujita,
  • Hiromasa Tachibana,
  • Tadashi Mio

DOI
https://doi.org/10.1111/1759-7714.15171
Journal volume & issue
Vol. 15, no. 3
pp. 271 – 273

Abstract

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Abstract Searching for driver gene alteration is a prerequisite for chemotherapy of non‐small cell lung cancer. Due to its high sensitivity and concordance rate, the Amoy Dx Pan Lung Cancer PCR panel has been approved and is widely used in Japan. In this report, we describe a case in which a positive result for Kristen rat sarcoma virus (KRAS) exon2 p.G12F, a rare KRAS mutation, may have led to a false‐positive result for KRAS exon2 p.G12C on AMOY. Genetic analysis in this case was performed by LC‐SCRUM‐Asia.

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