Molecular & Cellular Oncology (Mar 2017)

Targeting the AXL signaling pathway in ovarian cancer

  • Ruby Yun-Ju Huang,
  • Jane Antony,
  • Tuan Zea Tan,
  • David Shao-Peng Tan

DOI
https://doi.org/10.1080/23723556.2016.1263716
Journal volume & issue
Vol. 4, no. 2

Abstract

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In a recent publication in Science Signaling, we showed that a Mes molecular subtype of epithelial ovarian cancer (EOC) harboring epithelial-mesenchymal transition (EMT) features has a unique signaling network downstream of the GAS6/AXL pathway. Our finding leads to a potential strategy for treating the Mes subtype of EOC by targeting AXL.

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