Nature Communications (Jan 2018)

A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors

  • Zhengwen An,
  • Maja Sabalic,
  • Ryan F. Bloomquist,
  • Teresa E. Fowler,
  • Todd Streelman,
  • Paul T Sharpe

DOI
https://doi.org/10.1038/s41467-017-02785-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Mouse incisors constantly renew from a slow cycling population of mesenchymal stem cells. Here, the authors show that upon cutting of adult incisors, a sub-population of dental mesenchymal stem cells reactivates, allowing an increased growth rate and rapid regeneration.