Nature Communications (Mar 2023)
An integrated single cell and spatial transcriptomic map of human white adipose tissue
- Lucas Massier,
- Jutta Jalkanen,
- Merve Elmastas,
- Jiawei Zhong,
- Tongtong Wang,
- Pamela A. Nono Nankam,
- Scott Frendo-Cumbo,
- Jesper Bäckdahl,
- Narmadha Subramanian,
- Takuya Sekine,
- Alastair G. Kerr,
- Ben T. P. Tseng,
- Jurga Laurencikiene,
- Marcus Buggert,
- Magda Lourda,
- Karolina Kublickiene,
- Nayanika Bhalla,
- Alma Andersson,
- Armand Valsesia,
- Arne Astrup,
- Ellen E. Blaak,
- Patrik L. Ståhl,
- Nathalie Viguerie,
- Dominique Langin,
- Christian Wolfrum,
- Matthias Blüher,
- Mikael Rydén,
- Niklas Mejhert
Affiliations
- Lucas Massier
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Jutta Jalkanen
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Merve Elmastas
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Jiawei Zhong
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Tongtong Wang
- Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich
- Pamela A. Nono Nankam
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig
- Scott Frendo-Cumbo
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Jesper Bäckdahl
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Narmadha Subramanian
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Takuya Sekine
- Center for Infectious Medicine, Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Alastair G. Kerr
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Ben T. P. Tseng
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Jurga Laurencikiene
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Marcus Buggert
- Center for Infectious Medicine, Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Magda Lourda
- Center for Infectious Medicine, Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Karolina Kublickiene
- Department of Clinical Science, Intervention & Technology (CLINTEC), Unit of Renal Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge
- Nayanika Bhalla
- Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
- Alma Andersson
- Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
- Armand Valsesia
- Department of Metabolic Health, Nestle Institute of Health Sciences, Nestle Research
- Arne Astrup
- Department of Obesity and Nutritional Sciences, The Novo Nordisk Foundation
- Ellen E. Blaak
- Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre(+)
- Patrik L. Ståhl
- Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology
- Nathalie Viguerie
- Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Toulouse III - Paul Sabatier (UPS), Université de Toulouse
- Dominique Langin
- Institute of Metabolic and Cardiovascular Diseases (I2MC), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Toulouse III - Paul Sabatier (UPS), Université de Toulouse
- Christian Wolfrum
- Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, ETH Zurich
- Matthias Blüher
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig
- Mikael Rydén
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- Niklas Mejhert
- Department of Medicine Huddinge (H7), Karolinska Institutet, Karolinska University Hospital Huddinge
- DOI
- https://doi.org/10.1038/s41467-023-36983-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human datasets to provide a comprehensive cellular map of white adipose tissue.
