Nature Communications (Feb 2017)

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

  • Yun Teng,
  • Yi Ren,
  • Xin Hu,
  • Jingyao Mu,
  • Abhilash Samykutty,
  • Xiaoying Zhuang,
  • Zhongbin Deng,
  • Anil Kumar,
  • Lifeng Zhang,
  • Michael L. Merchant,
  • Jun Yan,
  • Donald M. Miller,
  • Huang-Ge Zhang

DOI
https://doi.org/10.1038/ncomms14448
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Exosomes are involved in the development of metastasis but how their composition is regulated is not well known. Here the authors propose that major vault protein-dependent loading of miR-193a into exosomes could be a general mechanism by which cancer cells get rid of oncosuppressor miRNAs.