Frontiers in Neurology (May 2021)

Glial Purinergic Signaling in Neurodegeneration

  • Marie J. Pietrowski,
  • Amr Ahmed Gabr,
  • Amr Ahmed Gabr,
  • Stanislav Kozlov,
  • David Blum,
  • David Blum,
  • Annett Halle,
  • Annett Halle,
  • Kevin Carvalho,
  • Kevin Carvalho

DOI
https://doi.org/10.3389/fneur.2021.654850
Journal volume & issue
Vol. 12

Abstract

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Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how dysregulated glial purinergic signaling and crosstalk may contribute to disease pathophysiology, thus bearing promising potential for the development of new therapeutical options for neurodegenerative diseases.

Keywords