Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

Qingyun Yang; Hui Qiu; Wei Guo; Dongmei Wang; Xingning Zhou; Dan Xue; Jinlan Zhang; Song Wu; Yinghong Wang

doi:10.3390/molecules200712114

Molecules (Jul 2015)

Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets

Qingyun Yang,
Hui Qiu,
Wei Guo,
Dongmei Wang,
Xingning Zhou,
Dan Xue,
Jinlan Zhang,
Song Wu,
Yinghong Wang

Affiliations

Qingyun Yang: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Hui Qiu: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Wei Guo: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Dongmei Wang: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Xingning Zhou: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Dan Xue: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Jinlan Zhang: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Song Wu: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China
Yinghong Wang: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical Colledge, Beijing 100050, China

DOI: https://doi.org/10.3390/molecules200712114
Journal volume & issue: Vol. 20, no. 7
pp. 12114 – 12124

Abstract

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A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method’s linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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