Nature Communications (Mar 2022)
CEP128 is involved in spermatogenesis in humans and mice
- Xueguang Zhang,
- Lingbo Wang,
- Yongyi Ma,
- Yan Wang,
- Hongqian Liu,
- Mohan Liu,
- Lang Qin,
- Jinghong Li,
- Chuan Jiang,
- Xiaojian Zhang,
- Xudong Shan,
- Yuliang Liu,
- Jinsong Li,
- Yaqian Li,
- Rui Zheng,
- Yongkang Sun,
- Jianfeng Sun,
- Xiangyou Leng,
- Yan Liang,
- Feng Zhang,
- Xiaohui Jiang,
- Yihong Yang,
- Ying Shen
Affiliations
- Xueguang Zhang
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Lingbo Wang
- Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University
- Yongyi Ma
- Department of Gynecology and Obstetrics, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yan Wang
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Hongqian Liu
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Mohan Liu
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Lang Qin
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Jinghong Li
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Chuan Jiang
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Xiaojian Zhang
- Sichuan Academy of Medical Sciences of Sichuan Provincial People’s Hospital
- Xudong Shan
- West China School of Basic Medical Sciences and Forensic Medicine
- Yuliang Liu
- Chengdu Research Base of Giant Panda Breeding
- Jinsong Li
- CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Yaqian Li
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Rui Zheng
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Yongkang Sun
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Jianfeng Sun
- Teaching Hospital of Chengdu University of TCM
- Xiangyou Leng
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Yan Liang
- Research Core Facility of West China Hospital, Sichuan University
- Feng Zhang
- Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University
- Xiaohui Jiang
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Yihong Yang
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- Ying Shen
- Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-022-29109-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
CEP128 is a centrosomal protein important for the organization of centriolar microtubules. Here, the authors show that a CEP128 variant observed in human male siblings causes reduced sperm counts and morphologically abnormal sperm when modeled in mice, suggesting a role for CEP128 in male fertility.
