Sensory TRP channels contribute differentially to skin inflammation and persistent itch

Jing Feng; Pu Yang; Madison R. Mack; Dariia Dryn; Jialie Luo; Xuan Gong; Shenbin Liu; Landon K. Oetjen; Alexander V. Zholos; Zhinan Mei; Shijin Yin; Brian S. Kim; Hongzhen Hu

doi:10.1038/s41467-017-01056-8

Nature Communications (Oct 2017)

Sensory TRP channels contribute differentially to skin inflammation and persistent itch

Jing Feng,
Pu Yang,
Madison R. Mack,
Dariia Dryn,
Jialie Luo,
Xuan Gong,
Shenbin Liu,
Landon K. Oetjen,
Alexander V. Zholos,
Zhinan Mei,
Shijin Yin,
Brian S. Kim,
Hongzhen Hu

Affiliations

Jing Feng: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Pu Yang: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Madison R. Mack: Division of Dermatology, Department of Medicine, The Center for the Study of Itch, Washington University School of Medicine
Dariia Dryn: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Jialie Luo: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Xuan Gong: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Shenbin Liu: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine
Landon K. Oetjen: Division of Dermatology, Department of Medicine, The Center for the Study of Itch, Washington University School of Medicine
Alexander V. Zholos: Department of Biophysics, Institute of Biology, Taras Shevchenko National University of Kyiv
Zhinan Mei: College of Pharmacy, South-Central University for Nationalities
Shijin Yin: College of Pharmacy, South-Central University for Nationalities
Brian S. Kim: Division of Dermatology, Department of Medicine, The Center for the Study of Itch, Washington University School of Medicine
Hongzhen Hu: Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-01056-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Allergic contact dermatitis is associated both with persistent itch and inflammation, but it is not known if these are mediated by shared signaling pathways. The authors show that persistent itch requires both TRPA1 and TRPV1, while TRPV1 has a protective role against skin inflammation in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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