Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system

Di Chuan; Min Mu; Huan Hou; Na Zhao; Jinglun Li; Aiping Tong; Bingwen Zou; Haifeng Chen; Bo Han; Gang Guo

Materials & Design (Aug 2021)

Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system

Di Chuan,
Min Mu,
Huan Hou,
Na Zhao,
Jinglun Li,
Aiping Tong,
Bingwen Zou,
Haifeng Chen,
Bo Han,
Gang Guo

Affiliations

Di Chuan: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
Min Mu: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
Huan Hou: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
Na Zhao: School of Pharmacy, Shihezi University, and Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi 832002, China
Jinglun Li: Department of Neurology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
Aiping Tong: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
Bingwen Zou: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.
Haifeng Chen: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China
Bo Han: School of Pharmacy, Shihezi University, and Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi 832002, China
Gang Guo: State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.

Journal volume & issue: Vol. 206
p. 109805

Abstract

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Epigallocatechin Gallate (EGCG) is the main component of green tea which can strongly bind to proteins, small molecular drugs, and DNA. Therefore, EGCG can be used to deliver biomacromolecules and drugs. In this study, a doxorubicin (DOX) delivery system (FPE/DOX NPs) based on the folic acid-functionalized EGCG was developed for the targeting therapy of ovarian cancer. Cellular uptake studies showed that FPE/DOX NPs enhanced DOX uptake by SKOV3 cells compared with PE/DOX NPs that without folic acid modification. In vitro, the toxicity of FPE/DOX NPs to SKOV3 cells was stronger than nanoparticles without folic acid modification. In vivo, the SKOV3 tumor growth inhibition effect of FPE/DOX NPs was substantially more effective than other groups. Together, the results of this study suggested that FPE/DOX NPs may have promising applications in ovarian cancer therapy.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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