Frontiers in Toxicology (Dec 2021)
Radiolabeling of Nanomaterials: Advantages and Challenges
- Wanqin Dai,
- Wanqin Dai,
- Wanqin Dai,
- Junzhe Zhang,
- Junzhe Zhang,
- Yun Wang,
- Yun Wang,
- Yun Wang,
- Chunlei Jiao,
- Chunlei Jiao,
- Chunlei Jiao,
- Zhuda Song,
- Zhuda Song,
- Zhuda Song,
- Yuhui Ma,
- Yuhui Ma,
- Yayun Ding,
- Yayun Ding,
- Zhiyong Zhang,
- Zhiyong Zhang,
- Zhiyong Zhang,
- Xiao He,
- Xiao He
Affiliations
- Wanqin Dai
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Wanqin Dai
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Wanqin Dai
- School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing, China
- Junzhe Zhang
- Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
- Junzhe Zhang
- Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing, China
- Yun Wang
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Yun Wang
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Yun Wang
- School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing, China
- Chunlei Jiao
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Chunlei Jiao
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Chunlei Jiao
- School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing, China
- Zhuda Song
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Zhuda Song
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Zhuda Song
- School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing, China
- Yuhui Ma
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Yuhui Ma
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Yayun Ding
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Yayun Ding
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Zhiyong Zhang
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Zhiyong Zhang
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- Zhiyong Zhang
- School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing, China
- Xiao He
- CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy of Sciences, Beijing, China
- Xiao He
- CAS-HKU Joint Laboratory of Metallomics on Health and Environment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
- DOI
- https://doi.org/10.3389/ftox.2021.753316
- Journal volume & issue
-
Vol. 3
Abstract
Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the “last-step” labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.
Keywords
- radiolabeling
- incorporation strategy
- derivatization strategy
- nanomaterials
- radiotracer technique
- in vivo stability
