Effect of Nandrolone Decanoate on Some Biochemical Markers When Used as Adjuvant Therapy for Healing of Facial Muscle Wound

Abstract

Aims: to distinguish if the nanodrolone decanoate has any effect on the healing of facial muscular wounds which are one of the issues that dentists face, and it is a challenge to find a useful treatment for this condition. This study explores the idea that, when used in conjunction with surgical repair. The steroid Nandrolone-Decanoate, when injected locally to the masseter muscle, improves healing. Materials and Methods: The study comprised twenty-five healthy rabbits, were sorted into three equal groups at random. The animals were classified randomly into 3 groups (5 rabbits/group). Group I: (control negative/5 rabbits) the rabbits were not undergoing surgical procedure and not receive any treatment. Group II: (control positive/10 rabbits) the rabbits were undergoing surgical procedure and receive distilled water injection. Group IIA: contained 5 rabbits that were euthanized on the 3rd day of the surgical procedure. Group IIB: contained 5 rabbits that were euthanized on the 7th day of the surgical procedure. Group III: (treatment/10 rabbits) the rabbits were undergoing surgical procedure, and each rabbit, treated once daily with nanodrolone deconate (10 mg/kg) using Mantoux syringe via intramuscular injection from the first day of the surgical procedure to the euthanizing day. Group IIIA: contained 5 rabbits that were euthanized on the 3rd day of the surgical procedure. Group IIIB: contained 5 rabbits that were euthanized on the 7th day of the surgical procedure. Results: There are highly significant differences in the serum aspartate aminotransferase (GOT) and Alanine aminotransferase (GPT). The results demonstrate an increase (both enzymes) in the treatment group on the seventh day of the trial as compared to the control group and the 3rd day. There is a decrease in the LDH (lactate dehydrogenase) level in the 7th day of the treatment as compared with 3rd day of treatment group and with the control group. C –reactive protein (CRP) serum results show a highly significant decrease in its level in 7th day as compared to the 3rd day and the control group. Conclusions: Nanodrolone Decanoate may be used as an adjunctive therapy in the healing of intramuscular wounds.

Keywords

• nandrolone-decanoate(nd) masseter muscle c- reactive protein(crp) lactate dehydrogenase(ldh) aspartate aminotransferase(got) alanine aminotransferase(gpt)