Frontiers in Cellular and Infection Microbiology (Feb 2021)

Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease

  • Xin Tan,
  • Huaisheng Chen,
  • Min Zhang,
  • Min Zhang,
  • Ying Zhao,
  • Yichun Jiang,
  • Xueyan Liu,
  • Wei Huang,
  • Wei Huang,
  • Yingfei Ma

DOI
https://doi.org/10.3389/fcimb.2021.631585
Journal volume & issue
Vol. 11

Abstract

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Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB). A personalized lytic pathogen-specific single-phage preparation was nebulized to the patient continuously for 16 days in combination with tigecycline and polymyxin E. The treatment was well tolerated and resulted in clearance of the pathogen and clinical improvement of the patient’s lung function.

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