Orthogonal control of mean and variability of endogenous genes in a human cell line

Alain R. Bonny; João Pedro Fonseca; Jesslyn E. Park; Hana El-Samad

doi:10.1038/s41467-020-20467-8

Nature Communications (Jan 2021)

Orthogonal control of mean and variability of endogenous genes in a human cell line

Alain R. Bonny,
João Pedro Fonseca,
Jesslyn E. Park,
Hana El-Samad

Affiliations

Alain R. Bonny: Department of Biochemistry and Biophysics, University of California, San Francisco
João Pedro Fonseca: Department of Biochemistry and Biophysics, University of California, San Francisco
Jesslyn E. Park: Department of Biochemistry and Biophysics, University of California, San Francisco
Hana El-Samad: Department of Biochemistry and Biophysics, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-020-20467-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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