EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Deepika Neelakantan; Hengbo Zhou; Michael U. J. Oliphant; Xiaomei Zhang; Lukas M. Simon; David M. Henke; Chad A. Shaw; Meng-Fen Wu; Susan G. Hilsenbeck; Lisa D. White; Michael T. Lewis; Heide L. Ford

doi:10.1038/ncomms15773

Nature Communications (Jun 2017)

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Deepika Neelakantan,
Hengbo Zhou,
Michael U. J. Oliphant,
Xiaomei Zhang,
Lukas M. Simon,
David M. Henke,
Chad A. Shaw,
Meng-Fen Wu,
Susan G. Hilsenbeck,
Lisa D. White,
Michael T. Lewis,
Heide L. Ford

Affiliations

Deepika Neelakantan: Department of Pharmacology, University of Colorado–Denver
Hengbo Zhou: Department of Pharmacology, University of Colorado–Denver
Michael U. J. Oliphant: Department of Pharmacology, University of Colorado–Denver
Xiaomei Zhang: Lester and Sue Smith Breast Center, Baylor College of Medicine
Lukas M. Simon: Institute of Computational Biology, Helmholtz Zentrum München (GmbH)
David M. Henke: Department of Molecular and Human Genetics, Baylor College of Medicine
Chad A. Shaw: Department of Molecular and Human Genetics, Baylor College of Medicine
Meng-Fen Wu: Lester and Sue Smith Breast Center, Baylor College of Medicine
Susan G. Hilsenbeck: Lester and Sue Smith Breast Center, Baylor College of Medicine
Lisa D. White: Department of Molecular and Human Genetics, Baylor College of Medicine
Michael T. Lewis: Lester and Sue Smith Breast Center, Baylor College of Medicine
Heide L. Ford: Department of Pharmacology, University of Colorado–Denver

DOI: https://doi.org/10.1038/ncomms15773
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI transcriptional program in neighbouring epithelial tumour cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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