Клинический разбор в общей медицине (Apr 2023)

Thyroid hormones in centenarians in coronary artery disease

  • Svetlana V. Topolyanskaya,
  • Tatyana M. Kolontai ,
  • Tatyana A. Eliseeva ,
  • Olga I. Turna,
  • Olga N. Vakulenko,
  • Leonid I. Bubman,
  • Margarita A. Romanova ,
  • Karine A. Lytkina ,
  • Georgii G. Melkonyan,
  • Svetlana A. Ratchina,
  • Leonid I. Dvoretsky

DOI
https://doi.org/10.47407/kr2023.4.4.00251
Journal volume & issue
Vol. 4, no. 4
pp. 13 – 19

Abstract

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Aim. To analyze the relationship of thyroid hormones with various clinical and laboratory parameters in centenarians with coronary artery disease (CAD) based on the determination of the blood concentration of thyroid-stimulating hormone (TSH), free triiodothyronine (T3) and free thyroxine (T4). Materials and methods. This work was a cross-sectional study conducted on the basis of the Hospital for War Veterans No. 3. The study enrolled 262 patients [195 (74.4%) women and 67 (25.6%) men] aged 90 to 101 years (mean age 92.9±2.5 years) hospitalized with a diagnosis of coronary artery disease. The concentration of thyroid-stimulating hormone (normal 0.27–4.2 μIU/ml), the level of free T4 (12–22 pmol/l) and free T3 (3.1–6.8 pmol/l) in the blood were determined. Results. The mean level of TSH was 3.1±3.1 μIU/ml (0.005–108), free T3 – 3.7±0.65 pmol/l (1.9–5.3), free T4 – 14.1±5.5 pmol/l (4.1–32). In 18.9% of patients, the level of TSH was elevated, in 3.9% it was reduced, in 77.2% of patients it was normal. In patients with increased TSH lower functional activity was noted, assessed using the Barthel index (66.9±23.0 compared to 75.0±16.4 points in patients with normal TSH; p=0.02) and the IADL scale (3.46±2.3 and 4.6±2.0 points, respectively; p=0.006). Direct correlations were registered between free T4 concentration and uric acid (r=0.28; p=0.05), cholesterol (r=0.35; p=0.01), triglycerides (r=0.37; p=0.08), hemoglobin (r=0.23; p=0.07) and Morse fall scale (r=0.34; p=0.05). Significant inverse correlations were established between the blood concentration of free T4 and absolute indicators of bone mineral density in the lumbar spine (r=-0.36; p=0.03), in the proximal left (r=-0.44; p=0.006) and right (r=-0.43; p=0.009) femur. Conclusion. The study results demonstrate the relationship between the concentration of thyroid hormones and various clinical and laboratory parameters in centenarians with coronary heart disease.

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