Nature Communications (Nov 2018)
TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
- Le Li,
- Lijia Li,
- Wei Li,
- Taiqi Chen,
- Bin Zou,
- Lina Zhao,
- Huili Wang,
- Xueying Wang,
- Lina Xu,
- Xiaohui Liu,
- Dong Wang,
- Bo Li,
- Tak W. Mak,
- Wenjing Du,
- Xiaolu Yang,
- Peng Jiang
Affiliations
- Le Li
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Lijia Li
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Wei Li
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Taiqi Chen
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Bin Zou
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Lina Zhao
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Huili Wang
- School of Medicine, Tsinghua University
- Xueying Wang
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Lina Xu
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Xiaohui Liu
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- Dong Wang
- School of Medicine, Tsinghua University
- Bo Li
- Zhongshan School of Medicine, Sun Yat-sen University
- Tak W. Mak
- The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital
- Wenjing Du
- State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Xiaolu Yang
- Department of Cancer Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
- Peng Jiang
- School of Life Sciences, Tsinghua University; Collaborative Innovation Center for Cancer Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07127-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis.
