Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

Isabel Ohs; Maries van den Broek; Kathrin Nussbaum; Christian Münz; Sebastian J. Arnold; Sergio A. Quezada; Sonia Tugues; Burkhard Becher

doi:10.1038/ncomms13708

Nature Communications (Dec 2016)

Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

Isabel Ohs,
Maries van den Broek,
Kathrin Nussbaum,
Christian Münz,
Sebastian J. Arnold,
Sergio A. Quezada,
Sonia Tugues,
Burkhard Becher

Affiliations

Isabel Ohs: Inflammation Research, Institute of Experimental Immunology, University of Zurich
Maries van den Broek: Tumor Immunology, Institute of Experimental Immunology, University of Zurich
Kathrin Nussbaum: Inflammation Research, Institute of Experimental Immunology, University of Zurich
Christian Münz: Viral Immunobiology, Institute of Experimental Immunology, University of Zurich
Sebastian J. Arnold: Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, and BIOSS Centre of Biological Signalling Studies, Albert-Ludwigs-University
Sergio A. Quezada: Research Department of Hematology, Cancer Immunology Unit, University College London Cancer Institute
Sonia Tugues: Inflammation Research, Institute of Experimental Immunology, University of Zurich
Burkhard Becher: Inflammation Research, Institute of Experimental Immunology, University of Zurich

DOI: https://doi.org/10.1038/ncomms13708
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Natural killer homeostasis is thought to be governed by gamma chain cytokines including IL-15. Here, the authors show that IL-12 can trigger the development of a distinct subset of natural killer cells with anti-tumour activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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